Saint Vincent de Paul’s downtown Los Angeles Thrift Store , the largest in Los Angeles County and one of the largest thrift stores in America, provides quality merchandise to those in need as well as a burgeoning trade with millennials and Gen Z. The secret is out that that this is the place to score a great bargain—and it’s a win-win as all proceeds go to support Saint Vincent de Paul’s various programs including the Cardinal Manning Center in the heart of Skid Row.