We replay the dramatic hours at a hotel room in Chicago leading up to Travis Kalanick’s resignation as the chief executive of Uber. Plus: Part I of a two-part series on the opioid crisis ravaging American cities, which has escalated to a whole new level with the spread of a drug 50 times more powerful than heroin. Guests: Mike Isaac, who has been writing about Mr. Kalanick for the last three years; and Nathaniel Popper, who covers finance and technology for The Times. Caitlin Dickerson is our host; Michael Barbaro is on vacation. For more information on today’s episode, visit http://nyti.ms/2sFqeM1.

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