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Toxic shock syndrome, bacterial exotoxins and SEPSIS 6 (3/3)
Insights:
Sepsis 6
Encapsulated bacteria (ANTIBIOTICS)
Hemodynamic problem (increased vasc permeability by loosening tight junctions between ECs) (FLUIDS, MEASURE URINE OUTPUT)
Metabolic disturbances (hyperglycaemia, insulin resistance, high cortisol, lactic acidosis (OXYGEN, VBG)
Acute kidney injury (URINE OUTPUT),
Bacterial exotoxins
Staph scalded syndrome - exfoliative A and B toxins against desmoglein 1 of desmosomes - epidermal peeling
Exotoxin superantigens (TSST1 Staph, Strep pyogenes, enterotoxin) - MHC II-mediated polyclonal T cell cytokine storm (TNF alpha, IL-1b) - rash, fever, hypotension, thrombi
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By Damian AmendraInsights:
Sepsis 6
Encapsulated bacteria (ANTIBIOTICS)
Hemodynamic problem (increased vasc permeability by loosening tight junctions between ECs) (FLUIDS, MEASURE URINE OUTPUT)
Metabolic disturbances (hyperglycaemia, insulin resistance, high cortisol, lactic acidosis (OXYGEN, VBG)
Acute kidney injury (URINE OUTPUT),
Bacterial exotoxins
Staph scalded syndrome - exfoliative A and B toxins against desmoglein 1 of desmosomes - epidermal peeling
Exotoxin superantigens (TSST1 Staph, Strep pyogenes, enterotoxin) - MHC II-mediated polyclonal T cell cytokine storm (TNF alpha, IL-1b) - rash, fever, hypotension, thrombi