Deep within all of us is an emptiness and longing, a soul-level thirst.
Jesus sees this deep within all of us and came to satisfy that longing. In John 4, Jesus has an intentional conversation with a woman who feels the emptiness of her soul. There are two things we should take from this.
First, that Jesus is the only one who can satisfy the longing of souls.
Second, as followers of Jesus, we should have these type of intentional conversations with our non believing friends and neighbors.