CannMed Coffee Talk

Training Yeast to Produce Cannabinoids with Andrew Horwitz, PhD


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We talk with Dr. Andrew Horwitz Vice President, R&D at Sestina Bio LLC about producing cannabinoids outside the cannabis plant. Previously, Andrew managed the Cannabinoid R&D program at Demetrix, where he helped develop the process for using genetically modified yeast cells to produce cannabinoids. We discuss:

  • The advantages of using yeast cells to produce cannabinoids instead of cannabis and hemp plants 
  • How adjusting the precursor molecules that are fed to the yeast cells can produce rare and novel cannabinoids
  • How cannabis medicine researchers can use this technology to better understand the entourage effect
  • Why understanding the way the cannabis plant produces cannabinoids was essential to developing this technology 
  • How this technology is received by the cannabis community 
  • Thanks to our Sponsor: Demetrix

    Demetrix is a biotechnology company that believes in the power of science to make the world a better place. The company produces safe, legal, and effective health and wellness products backed by science, including rare, high-purity cannabinoids for pharmaceutical and consumer applications.

    To learn more, please visit www.demetrixbio.com, and be sure to check out their blog, www.demetrixbio.com/insights

    Additional Resources

    • “Developing Fermentation Technology to Produce Specific Cannabinoids for Research and Consumer Use” Andrew Horwitz, PhD, CannMed 2019
    • Sestina Bio, LLC website
    • Demetrix blog
    • Luo, Xiaozhou et al. “Complete biosynthesis of cannabinoids and their unnatural analogues in yeast.” 
    • Inscripta Onyx
    • ...more
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