In this episode, we dive into a groundbreaking exploratory analysis from the Annals of Emergency Medicine examining the PATCH-Trauma trial. Researchers investigated the optimal timing for administering tranexamic acid (TXA) to patients with severe trauma, challenging the long-standing 3-hour window established by the CRASH-2 trial. The findings are striking...giving TXA within 90 minutes of injury significantly reduces 28-day mortality, while administration after 120 minutes may offer no benefit... Join us as we explore how these results could reshape trauma care guidelines and highlight the critical role of time-sensitive interventions in saving lives.

Ali A, Gruen RL, Bernard SA, Burns B, Forbes AB, Gantner DC, McArthur CJ, Maegele M, Mitra B; PATCH-Trauma trial investigators. Tranexamic Acid Timing and Mortality Impact After Trauma. Ann Emerg Med. 2025 Aug 1:S0196-0644(25)00989-8. doi: 10.1016/j.annemergmed.2025.06.609. Epub ahead of print. PMID: 40751727.

https://www.annemergmed.com/article/S0196-0644(25)00989-8/fulltext?rss=yes