Medizin - Open Access LMU - Teil 10/22

Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues


Listen Later

We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique. Tissues of three human subjects, obtained at autopsy, were analyzed. BNP transcripts could be detected in the central nervous system, lung, thyroid, adrenal, kidney, spleen, small intestine, ovary, uterus, and striated muscle. ANP transcripts could also be demonstrated in various human extracardiac tissues including several endocrine organs. In all peripheral tissues, the level of both natriuretic peptide transcripts was approximately 1-2 orders of magnitude lower than in cardiac ventricular tissues. This distribution is in marked contrast to the much lower level of ANP and BNP transcripts present in extracardiac rat tissues (generally less than 1/1000 of ventricles). These data suggest differential expression of the two natriuretic peptide genes in cardiac and extracardiac tissues in man. Furthermore, the presence of local synthesis of ANP and BNP in various peripheral organs suggests paracrine and/or autocrine function of these natriuretic peptides.
...more
View all episodesView all episodes
Download on the App Store

Medizin - Open Access LMU - Teil 10/22By Ludwig-Maximilians-Universität München


More shows like Medizin - Open Access LMU - Teil 10/22

View all
Multimedia-Programmierung - SoSe 2009 - Audio mit Folien by Prof. Dr. Heinrich Hußmann

Multimedia-Programmierung - SoSe 2009 - Audio mit Folien

0 Listeners

Einführung in die Ethnologie by Prof. Dr. Frank Heidemann

Einführung in die Ethnologie

0 Listeners

Multimedia im Netz - WiSe 2010 / 2011 - Audio mit Folien by Prof. Dr. Heinrich Hußmann

Multimedia im Netz - WiSe 2010 / 2011 - Audio mit Folien

0 Listeners

Theoretical Physics Schools (ASC) by The Arnold Sommerfeld Center for Theoretical Physics (ASC)

Theoretical Physics Schools (ASC)

2 Listeners

MCMP – Mathematical Philosophy (Archive 2011/12) by MCMP Team

MCMP – Mathematical Philosophy (Archive 2011/12)

6 Listeners

Hegel lectures by Robert Brandom, LMU Munich by Robert Brandom, Axel Hutter

Hegel lectures by Robert Brandom, LMU Munich

6 Listeners

MCMP – Philosophy of Science by MCMP Team

MCMP – Philosophy of Science

1 Listeners

MCMP – Philosophy of Physics by MCMP Team

MCMP – Philosophy of Physics

3 Listeners

Sommerfeld Lecture Series (ASC) by The Arnold Sommerfeld Center for Theoretical Physics (ASC)

Sommerfeld Lecture Series (ASC)

0 Listeners

LMU Grundkurs Strafrecht II (L-Z) SoSe 2015 by Prof. Dr. jur. Helmut Satzger

LMU Grundkurs Strafrecht II (L-Z) SoSe 2015

0 Listeners