This episode delves into the critical decision-making surrounding autologous bone flap preservation after decompressive craniectomy. Drawing from a systematic review and meta-analysis published in the Journal of Clinical Neuroscience in 2026, we examine the biological and clinical implications of both subcutaneous and cryogenic preservation methods. The abstract highlights the conflicting data regarding comparative effectiveness and the incomplete understanding of the biological relevance of these common practices. We will discuss the study's findings, which likely synthesize evidence from various sources to offer a clearer picture for clinicians managing patients who have undergone DC. This review aims to provide actionable insights to optimize patient outcomes by illuminating the advantages and disadvantages of each preservation technique. Please note this discussion is for informational purposes and does not constitute medical advice.