This episode delves into the critical question of optimal timing for cranioplasty following decompressive craniectomy. We review the systematic review and meta-analysis published in Brain and Behavior in 2026, examining the full text of the study. The analysis synthesizes data from various studies to compare early versus delayed cranioplasty in neurosurgical patients. Key findings regarding outcomes, complication rates, and patient recovery are discussed, offering valuable insights for clinical decision-making in managing patients who have undergone decompressive craniectomy. This information is intended for medical professionals and is not a substitute for professional medical advice.