In this episode, we delve into the critical question of optimal timing for cranioplasty following decompressive craniectomy. Based on a comprehensive systematic review and meta-analysis published in Brain and Behavior in 2026, we examine the full text to synthesize evidence on early versus delayed procedures. The review analyzes various study designs and patient populations to identify differences in outcomes such as infection rates, prosthetic complications, and functional recovery. This discussion aims to equip clinicians with the latest evidence to inform their decision-making in managing patients who have undergone decompressive craniectomy. This podcast is for informational purposes and does not constitute medical advice.