Jesse Mecham is a software developer and author of "You Need a Budget: The Proven System for Breaking the Paycheck-to-Paycheck Cycle, Getting Out of Debt, and Living the Life You Want." He talks with Jason Howell about the importance of budgeting and how he developed the YNAB software to help out.  
Host: Jason Howell 
Guest: Jesse Mecham 
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Triangulation 355: Jesse Mecham, YNAB

Every week TWiT hosts talk to the smartest people in the world about the most important topics in technology. Join Leo Laporte and other TWiT hosts for these enlightening one-on-one interviews.

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In a wide-ranging conversation, Leo Laporte talks with Dr. George Church about the history and future of genome sequencing. Dr. Church explains why he is very excited about how they made an organism resistant to all viruses- both known and unknown.   
They also talk about:  
How Dr. Church made sequencing affordable (from $3BN to $600) 
Where are we on sequencing the entire human genome, and why would we even want to? 
How close are we to reversing aging?  
Should we use gene therapy to double the human lifespan? 
Why genetically engineering cold-resistant elephants could be important for climate change, and what about ultimately bringing back the Mammoth? 
He explains the difference between the hype and reality of CRISPR 
sequencing, synthesis, and delivery 
What are the privacy concerns about companies sharing your genome? 
They discuss the controversy and benefit of reconstructing old viruses like the 1918 flu and even inventing new viruses. 
Dr. Church is a professor of genetics at Harvard Medical School and a pioneer in personal genetics. He is credited with developing the first methods for sequencing the first genome and also the CRISPR technology. He created several companies, including Nebula Genomics and Veritas Genetics. 
Host: Leo Laporte 
Guest: Dr. George Church 
Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 433: The Father of Modern Genomics - George Church

New York Times bestselling author Daniel Suarez returns to talk with Leo Laporte about the second book in his 'Delta-v' novel series, 'Critical Mass,' where a group of pioneering astropreneurs must overcome never-before-attempted engineering challenges to rescue colleagues stranded at a distant asteroid—kicking off a new space race in which Earth's climate crisis could well hang in the balance.  
Get 'Critical Mass': https://amzn.to/3Yjb9xu 
Host: Leo Laporte 
Guest: Daniel Suarez 
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Triangulation 432: Daniel Suarez: Critical Mass - Daniel Suarez on his latest book 'Critical Mass'

Writer/activist Cory Doctorow and scholar Rebecca Giblin join Leo Laporte to talk about their latest book Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back. They argue that we're in a new era of "chokepoint capitalism," with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others. 
Get "Chokepoint Capitalism": https://chokepointcapitalism.com 
Host: Leo Laporte 
Guests: Cory Doctorow and Rebecca Giblin 
Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 431: Cory Doctorow and Rebecca Giblin: Chokepoint Capitalism - How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back

Tripp Mickle joins Leo Laporte to discuss his new book, "After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul". They discuss the shift in Apple's dynamic and approach to products after the passing of Steve Jobs from a company of innovation with Jony Ive, to a company of efficiency under Tim Cook. 
Host: Leo Laporte 
Guest: Tripp Mickle 
Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 430: Tripp Mickle: After Steve - A Conversation with Tripp Mickle

Amy Webb joins Leo Laporte to discuss her new book, "The Genesis Machine." Webb explains synthetic biology, tells the story of golden rice, and shares a glimpse of the future and the changes we can expect. 
Get "The Genesis Machine": https://amzn.to/3BC7K2t 
Host: Leo Laporte 
Guest: Amy Webb 
Download or subscribe to this show at https://twit.tv/shows/triangulation.

Triangulation 355: Jesse Mecham, YNAB

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