Generic Name trimethoprim/sulfamethoxazole Trade Name Bactrim/TMP-SMZ Indication

bronchitis, UTI, diarrhea, pneumonia, multiple types of infection

Action

bacteriacidal by preventing metabolism of folic acid

Therapeutic Class

anti-infectives, antiprotozoals

Pharmacologic Class

folate antagonists, sulfonamides

Nursing Considerations

• may cause renal damage, Steven Johnsons Syndrome – rash, pseudomembranous colitis, nausea, vomiting, diarrhea, rash, agranulocytosis, aplastic anemia, phlebitis • contraindicated with sulfa allergies • monitor CBC • obtain cultures prior to initiating therapy • monitor intake and output • instruct patient to complete dose • drink 8-10 glasses of water