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Tu cuerpo transforma el paracetamol en analgesico
Te explico como funciona el acetaminofen, su mecanismo de acción detallado . Explicamos dosis día, máxima y toxicidad. Que dice la ciencia recientemente sobre estos mecanismos: 1. Przybyła GW, Szychowski KA, Gmiński J. Paracetamol – An old drug with new mechanisms of action. Clin Exp Pharmacol Physiol. 2020;1–17. doi: 10.1111/1440-1681.13392.2. Mallet C, Desmeules J, Pegahi R, Eschalier A. An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact. J Pain Res. 2023;16:1081–1094.3. Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth. 2008;18(10):915–921.4. Ohashi N, Kohno T. Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action. Front Pharmacol. 2020;11:580289.5. Maatuf Y, Kushnir Y, Nemirovski A, Ghantous M, Iskimov A, Binshtok AM, Priel A. The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels. Proc Natl Acad Sci U S A. 2025 Jun 4.
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By Eduardo A Fontanilla R, MD MScTe explico como funciona el acetaminofen, su mecanismo de acción detallado . Explicamos dosis día, máxima y toxicidad. Que dice la ciencia recientemente sobre estos mecanismos: 1. Przybyła GW, Szychowski KA, Gmiński J. Paracetamol – An old drug with new mechanisms of action. Clin Exp Pharmacol Physiol. 2020;1–17. doi: 10.1111/1440-1681.13392.2. Mallet C, Desmeules J, Pegahi R, Eschalier A. An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact. J Pain Res. 2023;16:1081–1094.3. Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth. 2008;18(10):915–921.4. Ohashi N, Kohno T. Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action. Front Pharmacol. 2020;11:580289.5. Maatuf Y, Kushnir Y, Nemirovski A, Ghantous M, Iskimov A, Binshtok AM, Priel A. The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels. Proc Natl Acad Sci U S A. 2025 Jun 4.