This episode delves into the prognostic impact of surgical strategies and extent of resection in patients with primary central nervous system lymphoma (PCNSL) undergoing methotrexate-based treatment. Based on an abstract from "Prognostic Assessment of Surgical Strategies and Extent of Resection in Methotrexate-Based Treatment for Primary Central Nervous System Lymphoma: A Propensity-Matched Analysis" published in World Neurosurgery in 2026, this analysis utilizes a propensity-matched approach to explore how different surgical interventions and the degree of tumor removal influence clinical outcomes in this challenging malignancy. Key findings regarding the significance of surgical approaches and resection extent will be discussed, offering valuable insights for oncologists and neurosurgeons managing PCNSL patients. This content is for informational purposes only and does not constitute medical advice. AI has been used to summarize the provided abstract.