The hosts primarily discuss Twinmotion and Unreal Engine, focusing on how they can be used for real-time visualization and virtual production in the architecture, film, and gaming industries. They emphasize the ease of use of Twinmotion for quickly creating and iterating on designs, while Unreal Engine allows for more advanced interactivity and customization. The hosts showcase various applications, including virtual scouting, stage planning, collaborative workflows, and exporting designs to LED walls for virtual production.