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Ulcerative Colitis - Medical Management
Tailored for surgeons, this review covers when medical therapy has failed. We discuss the shift from symptom control to "mucosal healing" and the specific risks of 5-ASAs and thiopurines (TPMT testing). The episode details the management of Acute Severe UC (ASUC) using modified Truelove and Witts criteria, the timeline for "salvage therapy" (Infliximab vs. Cyclosporine), and the danger of "sequential salvage" which delays necessary colectomy.
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By Allen Kamrava, MD MBA FACS FASCRSTailored for surgeons, this review covers when medical therapy has failed. We discuss the shift from symptom control to "mucosal healing" and the specific risks of 5-ASAs and thiopurines (TPMT testing). The episode details the management of Acute Severe UC (ASUC) using modified Truelove and Witts criteria, the timeline for "salvage therapy" (Infliximab vs. Cyclosporine), and the danger of "sequential salvage" which delays necessary colectomy.