In this episode of 'Not Your Doc...Anymore' hosted by Daren Watts, Dr. Ryan Watts, PhD, discusses his journey from contemplating a life in medicine to becoming a prominent figure in neuroscience and biotechnology. Dr. Watts shares insights into his academic background, including his switch from medical training to obtaining a PhD in science at Stanford University and his impactful career at Genentech, where he led the company's reentry into neuroscience. The episode highlights Watts' founding of Denali Therapeutics, its advancements in treating neurodegenerative diseases like Parkinson's, Alzheimer's, and ALS, and the proprietary blood-brain barrier platform developed by his team. The conversation covers the challenges of scientific discovery, the impact of the pharmaceutical industry, the scientific method, and the importance of evidence-based medicine. The episode also touches on the roles of collaboration, ethical considerations, and the public perception of science amidst misinformation. Through personal anecdotes and professional insights, Dr. Watts emphasizes the significance of persistence, resilience, and collaboration in achieving breakthroughs in neurotherapeutics.

00:00 Introduction to the Podcast

00:26 Meet Dr. Ryan Watts

01:32 Ryan's Career Journey

02:11 Denali Therapeutics and Recent Achievements

09:33 Challenges in Medicine and Science

20:41 Understanding the Scientific Method

28:30 Stages of Drug Development

32:38 The Promise of Molecular Medicines for Alzheimer's

33:25 Understanding Amyloid Plaques

34:13 Genetic Discoveries and Alzheimer's Risk

37:03 Challenges in Drug Development

37:40 The Cost and Regulation of Drug Development

41:44 The Role of Collaboration in Science

44:34 Ethical Considerations and Intellectual Property

46:31 Misinformation and Public Perception

53:25 Evaluating Online Information

58:44 The Impact of Scientific Discoveries on Personal Lives

01:00:32 Improving the Healthcare System

01:03:22 Final Thoughts and Acknowledgements