Link to bioRxiv paper:

http://biorxiv.org/cgi/content/short/2020.07.31.230896v1?rss=1

Authors: McLeod, D. V., Gandon, S.

Abstract:

The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood. Here we argue that studying MDR evolution by focusing upon the dynamical equations for linkage disequilibrium (LD) can greatly simplify the calculations, generate more insight, and provide a unified framework for understanding the role of population structure. We demonstrate how a general epidemiological model of MDR evolution can be recast in terms of the LD equations. These equations reveal how the different forces generating and propagating LD operate in a dynamical setting at both the metapopulation and population level. We then apply these insights to show how the LD perspective: (i) provides a simple interpretative framework for transient evolutionary dynamics, (ii) explains equilibrium patterns of MDR, and (iii) can be used to assess the MDR consequences of different drug prescription strategies.

Copy rights belong to original authors. Visit the link for more info