Recent research has revealed that the prelimbic cortex, a part of the medial prefrontal cortex, plays a crucial role in the dynamics of addiction, particularly concerning the substance propofol. By employing optogenetics to manipulate glutamatergic neurons in this area, scientists found that activating these neurons heightened locomotor sensitization to propofol, while inhibition had the opposite effect. This study emphasizes the significance of AMPA receptors in addiction processes and suggests that understanding these biological pathways can inform more effective treatment approaches for those struggling with substance use disorders. 
Source: https://onlinelibrary.wiley.com/doi/10.1111/adb.70078?af=R

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