In this episode, we delve into how the adaptive immune system responds to SARS-CoV-2 within the nasal lymphoid tissue—the first line of defense in the respiratory tract. We explore the roles of T cells, B cells, and memory responses that develop in the nasal mucosa, highlighting recent research that offers clues to long-lasting immunity and vaccine design. This conversation bridges virology, immunology, and clinical application, shedding light on the importance of mucosal immunity in both infection resolution and future pandemic preparedness.