Can real-time transepidermal water loss (TEWL) monitoring reduce the risk of anaphylaxis during oral food challenges in young children with peanut allergy? A pilot trial suggests it may. TEWL-guided stopping significantly lowered anaphylaxis rates and reaction severity without delaying treatment. This benefit was linked to earlier discontinuation of allergen exposure based on physiologic changes, rather than faster intervention. While larger studies are needed, these findings support TEWL monitoring as a promising tool to enhance safety and decision-making during food challenges. Learn more in this episode of AudioAbstracts.