In this episode of Take as Directed, J. Stephen Morrison speaks with Dr. Heidi Larson, Director of the Vaccine Confidence Project at the London School of Hygiene and Tropical Medicine. They discuss why vaccine confidence is currently in crisis, and how this has fueled outbreaks such as measles and the persistence of polio in Afghanistan and Pakistan. Plus, Dr. Larson walks through her work with the Vaccine Confidence Project, including monitoring public confidence in immunization programs and building an information surveillance system for early detection of public concerns around vaccines.