Welcome to the inaugural episode of The Bonehead Podcast, where we break down a randomized controlled trial paper titled “Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures” published in the journal JAMA Surgery in March 2021. Here, we provide a ten-minute summary of the key findings and clinical correlations, as well as introduce some valuable educational points for our medical student listeners, such as the importance of randomization and blinding.