Due to large, complex and therefore sensitive molecules, biologics pose a challenge to standard drug containment solutions. Their sensitivity towards leachables, the necessity of lyophilization or their tendency to adsorb might require a special inner glass surface quality. Storage at deep cold temperatures pose additional challenges with regard to container closure integrity and strength. Their high value put even more pressure on the reduction of final rejects and on the ability for track-and-trace on unique container level.

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