Vicissitude is a noun that refers to a change of circumstances or fortune. 

The Latin word vicissim (vee CHEESE eem) means ‘by turns or changes.’ Our word of the day has been English since the early 17th century. Here’s an example of it in use:

The daily vicissitudes of owning a business were simply too stressful for me to take. Whether it was ordering mustard or ketchup or buns or wieners, operating a hot dog stand had so many changes, I just couldn’t keep up.