Thiazide diuretics are a first-line treatment for patients with high blood pressure (BP), either as monotherapy or, more often, in combination with other first-line agents, but which one should clinicians use? Chlorthalidone was used in several landmark clinical trials and has a favorable pharmacokinetic profile.  But hydrochlorothiazide is the most commonly used (and cheapest) thiazide.

Guest Authors: Brian T Terrell, PharmD, BCACP and Eric J MacLaughlin, PharmD, BCPS

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