This episode discusses four MMWR reports. First, a norovirus outbreak with more than 300 cases in Illinois is linked to an ill worker who continued working while sick. Second, COVID-19 vaccines protect young children against COVID-19-associated emergency department and urgent care visits. Third, adults older than 50 who received the JYNNEOS vaccine had lower rates of hospitalization with mpox. For the best protection, all eligible adults should receive 2 doses of JYNNEOS vaccine, regardless of childhood smallpox vaccination status. Finally, increased vaccination and prompt virus detection are needed to eradicate polio in Pakistan.