This episode discusses five MMWR reports. First, a new CDC study shows that updated COVID-19 vaccines protect against symptomatic illness, including infections caused by the JN.1 variant. Second, Neptune's Fix, a flavored tianeptine elixir sold in gas stations, convenience stores, and online, is associated with serious clinical outcomes in 17 patients in New Jersey. Third, acute flaccid myelitis, or AFM, remained low in the U.S. between 2019 and 2022 despite increased circulation of EV-D68, an enterovirus previously connected to an increase in AFM cases. Fourth, Peru reported its largest dengue outbreak in 2023.