This episode discusses five MMWR reports. The first report highlights the effectiveness of the mRNA vaccine during Omicron predominance. The second report looks at COVID-19 vaccine booster doses among people with weakened immune systems. The third report examines factors associated with severe outcomes among adults with weakened immune systems hospitalized for COVID-19. The fourth report examines county-level social vulnerability and emergency department visits for firearm injuries. The last report highlights rapid diagnostic testing for monkeypox.