This episode discusses four MMWR reports. First, recent increases in fleaborne typhus cases and deaths in Los Angeles County highlight the importance of avoiding fleas found on rodents, opossums, and feral cats. Patients with suspected illness should be treated as soon as possible. Second, multifaceted interventions are critical to limiting multidrug-resistant organism spread in health care settings. Third, nearly all children who tested positive for measles in a recent outbreak had not received their measles, mumps, and rubella vaccine. Finally, a new CDC review further supports the safety of the Novavax COVID-19 vaccine among people 12 and older.