This episode discusses four MMWR reports. First, breakthrough cures for hepatitis C still fail to reach most Americans who need them. A transformative national response is needed. Second, xylazine mixed with fentanyl emerges as a public health threat, increasingly detected in overdose deaths. Third, targeted vaccination in LA County had a greater impact on COVID-19 infections in lower-income communities than in higher-income communities. Finally, many international travelers returning to the United States with travel-related health conditions did not seek health care before travel.