This episode discusses four MMWR reports. First, although the number of mpox cases has decreased since the peak of the U.S. outbreak in August 2022, the risk for future outbreaks remains. Clinicians need to be alert for new cases and people at risk should continue to take prevention measures. Second, a new report looking at data from 12 U.S. jurisdictions shows the JYNNEOS vaccine is effective at preventing mpox in people at high risk for mpox. Third, a study of mpox patients in New York provides additional evidence showing the JYNNEOS vaccine is highly effective against mpox. Finally, a new report looks at which occupations had the highest, or lowest, percentages of workers with disability.