This episode discusses four MMWR COVID-19 reports. The first report details the importance of COVID-19 vaccination for adolescents and mask use for those not yet vaccinated. Another report describes excess deaths in patients with end-stage renal disease during the early months of COVID-19. The third report focuses on how people living with severe HIV disease in sub-Saharan Africa were more likely to have severe outcomes from COVID-19. And the final report highlights how COVID-19 surveillance data in South Sudan and other countries are likely to have been affected by changes in strategy, funding, and policy.