This episode discusses four MMWR reports. First, lack of timely testing and inadequate treatment contributed to almost 90% of congenital syphilis cases in the U.S. in 2022. Second, chronic obstructive pulmonary disease trends are stable, but disparities persist by age, sex, education, and rural residence. Third, the first occupational asthma death in a U.S. cannabis production worker has been reported. Finally, invasive pneumococcal disease was identified among people experiencing homelessness in Colorado.