This episode discusses six MMWR reports. The first report describes strategies adopted by men who have sex with men to prevent monkeypox transmission. The second report uses a simulated model to examine monkeypox spread among men who have sex with men The third report details HIV and sexually transmitted infections among people with monkeypox. The fourth report highlights the use of tecovirimat (also known as Tpoxx) for the treatment of monkeypox in the United States. The fifth report looks at monkeypox testing challenges in low-risk populations. And the last report looks at detection of vaccine-derived polioviruses in children with weakened immune systems.