Weight loss drugs, like semaglutide and tirzepatide, based on gut hormones, are effective but may cause significant loss of muscle and bone mass, impacting long-term health. This loss stems from increased muscle protein breakdown and reduced bone stress. To mitigate these risks, individuals should increase protein intake, engage in resistance training, and maintain regular physical activity. While the long-term effects are still being studied, combining medication with lifestyle changes is currently the best approach.

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