Drugs prescribed and administered solely under specialist care or as part of clinical trials, without being specifically recorded in GPs’ prescribing systems, can have serious consequences for patient safety. Here, in our second podcast, Dr Pawan Randev, general practitioner and primary care cancer lead, and Dr Ike Iheanacho, DTB Editor, discuss these issues. This is an extension of our April 2009 Editorial, What are you on? (DTB 2009; 47: 37).