This week I'm so thrilled to interview Dr. Stephen Hauser, author of "The Face Laughs While the Brain Cries." He discusses a remarkable career as a physician-scientist, in which he uncovered a key role for B cells in the debilitating autoimmune disease multiple sclerosis. More remarkably, his perseverance led to the transformative drugs that are now available for this disease, emphasizing the importance of basic science for addressing long-standing healthcare challenges and the unique lens that practicing physicians can bring to biomedical research.