Pastor Derek Anglin preaches from Ephesians 2 about the transformative power of God's grace in people's lives. He addresses the question 'What happened to them?' when people notice dramatic changes in those who have encountered Jesus. The sermon explains that before salvation, we were spiritually dead in our sins, walking according to the ways of the world and under Satan's influence. However, God intervened with His rich mercy and great love, making us alive with Christ even though we were dead in our trespasses. This transformation is entirely by grace through faith, not by works, so that no one can boast. The pastor concludes with a powerful illustration of grace as a rescue boat that comes to save a drowning person who cannot save themselves, emphasizing that God's grace pursues us even when we resist, and salvation comes entirely through His power and initiative.