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What Happens When Depressive Disorder Goes Untreated? Depressive disorder, particularly major depressive disorder (MDD) or persistent depressive disorder (dysthymia), is a serious mental health condition that affects millions of people worldwide. Left untreated, depression can have profound effects on nearly every aspect of an individual’s life. The consequences of untreated depression can range from physical health problems to emotional suffering and social difficulties, and may even increase the risk of more severe mental health conditions. In this article, we will explore the potential consequences of untreated depressive disorder, including its impact on relationships, physical health, mental health, and quality of life.