This episode of Techsplainers explores AutoGen, Microsoft Research's innovative open-source framework that enables multiple AI agents to collaborate through conversation. Unlike traditional single-agent systems, AutoGen creates teams of specialized AI assistants that can communicate with each other to tackle complex problems. We examine how AutoGen configures diverse agents with different roles and expertise, establishes a structured dialogue system between them, and integrates external tools and APIs to expand their capabilities. The discussion highlights practical applications across software development, data analysis, education, and content creation, where agent collaboration produces more comprehensive solutions than individual AI systems could achieve alone. While emphasizing AutoGen's unique approach to multi-agent conversation and autonomous collaboration, we also address the framework's current limitations and the continued importance of human oversight in maximizing its effectiveness. Find more information at https://www.ibm.com/think/topics/autogen Find more episodes https://www.ibm.biz/techsplainers-podcast Narrated by Cole Stryker