What is Spravato and Ketamine? The short answer is that Spravato is an FDA approved medicine for Treatment-Resistant Depression (TRD) and depressive symptoms in adults with Major Depressive Disorder (MDD), who also have thoughts of self harm. Ketamine is the parent medicine that's used for all kinds of things. In this episode we share more about what it is and why you might be interested in getting treatment with it.