Tramadol has shown major drug interactions with medications such as Ambien (zolpidem), Cymbalta (duloxetine), Flexeril (cyclobenzaprine), gabapentin, hydrocodone, Lyrica (pregabalin), Norco (acetaminophen / hydrocodone), Percocet (acetaminophen / oxycodone), Suboxone (buprenorphine / naloxone), Xanax (alprazolam),  and Zoloft (sertraline).

https://recoverypartnernetwork.com/drug/opioid/tramadol-addiction