Complicating The Narrative

What the data can and cannot tell us about our health with Katherine Keyes


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Katherine Keyes joins Salma to discuss the strengths and limitations of epidemiology, beginning with the gap between what averages tell us about populations and what they fail to predict about individuals. They explore how that gap is a frequent source of public misunderstanding, how self-experimentation can mislead through placebo effects and confounding, and why public health needs to be more transparent and humble about the strengths and limitations of its evidence base. As Katherine and Salma argue, the public can handle nuance when it is communicated honestly.

They then turn to what makes a research question worth asking, arguing that good questions should aim probe where existing theories produce anomalies in addition to expanding the existing evidence base, and that the questions any of us can ask are shaped by the "thought collectives" we operate within. Drawing on Katherine's work in psychiatric epidemiology, they discuss why rising mental health trends are likely multifactorial, before closing on the importance of engaging communities and carrying knowledge beyond traditional academic environments.

This episode invites you to look beyond the data, to understand the context in which it was produced, recognize its limits, and consider what it means to communicate those limits honestly to the public.

 

About the guest:

Dr. Katherine Keyes is the Susan Lasker Brody Professor of Population Mental Health and Vice Chair for Research at the Columbia Mailman School of Public Health. Her research focuses on psychiatric and substance use epidemiology across the life course, with a particular interest in methodological challenges and in outcomes such as suicide and overdose.

 

Notes:

Acronyms mentioned in this episode include:

  • DSM = Diagnostic and Statistical Manual of Mental Disorders
  • GLP-1 = Glucagon-Like Peptide-1
  • RCT = Randomized Controlled Trial
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    Useful resources:

    • Keyes KM. What Makes Something Worth Knowing? Epistemology and Public Health Impact. Epidemiology. 2026;37(3):371-373. doi:1097/EDE.0000000000001957
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      Host: Dr. Salma Abdalla

      Editors: Catalina Melendez Contreras

      Marketing: Kinkini Bhaduri

      Music: Eden Avery / Melting Glass from Epidemic Sound https://www.epidemicsound.com/track/2fqOXWpHab/

       

      The views and opinions expressed by the guest in this episode do not necessarily reflect those of their institution, the funders, or the podcast team. 

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      Complicating The NarrativeBy Salma Abdalla