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Who Benefits Most from Brain Training and Exercise in Progressive MS
People with progressive multiple sclerosis often experience slowed cognitive processing speed. Researchers from Kessler Foundation analyzed data from the international CogEx trial, involving over 300 participants using brain training and exercise over 12 weeks. They found that improvement in cognitive speed varied, with better memory and higher pre-symptom IQ predicting greater gains. Factors like age, gender, or disability status did not affect outcomes. These findings highlight the need for personalized rehabilitation tailored to individuals’ cognitive profiles, moving beyond one-size-fits-all treatments.
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Kessler Foundation Investigators:
Lead: Brian Sandroff, PhD
https://kesslerfoundation.org/about-us/foundation-staff/brian-m-sandroff-phd
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READ this journal article:
“Correlates of Processing Speed Change With Combined Cognitive Rehabilitation and Exercise in Progressive MS: Secondary Analysis of the CogEx Trial,” was published in Neurorehabilitation & Neural Repair (2025), https://journals.sagepub.com/doi/10.1177/15459683251331586
PARTICIPATE:
Interested in participating in our research remotely or in-person? Go to https://kesslerfoundation.org/join-our-research-studies
LISTEN to more Real-Life Science Summaries:
https://soundcloud.com/kesslerfoundation/sets/real-life-science
This Real-Life Science summary is part of our series that translates peer-reviewed research into practical, real-world understanding.
=====================================================================================
LOOKING FOR MORE PODCASTS?
Join our listeners in 90 countries who enjoy learning about the work of Kessler Foundation. Subscribe to our SoundCloud channel, “KesslerFoundation,” for more research updates.
This podcast was recorded, produced, and edited by Joan Banks-Smith, Sr. Creative Producer at Kessler Foundation in December 2025.
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Kessler Foundation uses AI voices and narrators to make our media more accessible. These tools help ensure people with visual or cognitive impairments can access our materials. Automated voices may not always capture intonation or pronunciation as clearly as the accompanying text. If you experience issues with our AI narrators, please contact us at [email protected].
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By Kessler Foundation
5
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People with progressive multiple sclerosis often experience slowed cognitive processing speed. Researchers from Kessler Foundation analyzed data from the international CogEx trial, involving over 300 participants using brain training and exercise over 12 weeks. They found that improvement in cognitive speed varied, with better memory and higher pre-symptom IQ predicting greater gains. Factors like age, gender, or disability status did not affect outcomes. These findings highlight the need for personalized rehabilitation tailored to individuals’ cognitive profiles, moving beyond one-size-fits-all treatments.
=====================================================================================
Kessler Foundation Investigators:
Lead: Brian Sandroff, PhD
https://kesslerfoundation.org/about-us/foundation-staff/brian-m-sandroff-phd
=====================================================================================
READ this journal article:
“Correlates of Processing Speed Change With Combined Cognitive Rehabilitation and Exercise in Progressive MS: Secondary Analysis of the CogEx Trial,” was published in Neurorehabilitation & Neural Repair (2025), https://journals.sagepub.com/doi/10.1177/15459683251331586
PARTICIPATE:
Interested in participating in our research remotely or in-person? Go to https://kesslerfoundation.org/join-our-research-studies
LISTEN to more Real-Life Science Summaries:
https://soundcloud.com/kesslerfoundation/sets/real-life-science
This Real-Life Science summary is part of our series that translates peer-reviewed research into practical, real-world understanding.
=====================================================================================
LOOKING FOR MORE PODCASTS?
Join our listeners in 90 countries who enjoy learning about the work of Kessler Foundation. Subscribe to our SoundCloud channel, “KesslerFoundation,” for more research updates.
This podcast was recorded, produced, and edited by Joan Banks-Smith, Sr. Creative Producer at Kessler Foundation in December 2025.
=====================================================================================
Kessler Foundation uses AI voices and narrators to make our media more accessible. These tools help ensure people with visual or cognitive impairments can access our materials. Automated voices may not always capture intonation or pronunciation as clearly as the accompanying text. If you experience issues with our AI narrators, please contact us at [email protected].