This Episode examine the growing global threat of fungal pathogens to human, animal, and plant health within the context of globalization and climate change. Rapid environmental shifts and international trade facilitate the spread of invasive species, such as the multidrug-resistant Candida auris and virulent wheat stem rust. The texts highlight how antifungal resistance is exacerbated by the overlapping use of similar chemical treatments in both clinical and agricultural settings. To mitigate these risks, researchers advocate for the One Health approach, which integrates human, veterinary, and environmental monitoring. Innovative solutions discussed include genetic diversity exploitation, advanced air-sampling technologies, and novel biocontrol agents like antifungal proteins and RNA interference. Ultimately, the collection emphasizes that early detection systems and international cooperation are vital to safeguarding global food security and public health.