There are many potential risks associated with ayahuasca, such as respiratory arrest, seizures, coma, severe diarrhea, and vomiting. Another potential side effect of using ayahuasca is serotonin syndrome. People who are on antidepressants are more likely to get serotonin syndrome if they use DMT/ ayahuasca alongside the antidepressants.

https://recoverypartnernetwork.com/drug/illicit/ayahuasca-addiction-and-abuse