The podcast explains the benefits of using the MediatR library in .NET applications. It details how MediatR simplifies application architecture by promoting loose coupling and separation of concerns, making code cleaner and more testable. The document also explains how MediatR can implement CQRS, a pattern separating commands and queries, improving application scalability and maintainability. Finally, the document provides a step-by-step guide on how to get started with MediatR, including installation instructions, configuration, and a basic example of using a query and its handler.