This Episode explore the complex relationship between biological systems, genetics, and environmental factors in determining human health and disease. They examine how genomic diversity and enzymatic variations, such as those in the CYP2B6 and FLG genes, influence everything from drug metabolism and personalized therapy to the development of atopic dermatitis. Research also highlights the physiological impact of aging and chronic stress, particularly through the lens of allostatic load and hormonal changes that erode the body’s natural homeostasis. Furthermore, the texts emphasize the critical role of the microbiome and skin barrier function in maintaining wellness and regulating immune responses. Beyond physical health, the documents address psychological wellbeing, noting how social comparisons and visible skin conditions can negatively affect self-esteem. Finally, the collection warns of survivorship bias in research, urging a more inclusive approach to clinical trials and data analysis across diverse global populations.