In this episode of the Sober Head podcast, Dr. Esra Çavuşoğlu, PhD, hosts Dr. Sandra Kaufmann, MD. She, a longevity physician, completed her residency in pediatric anesthesia at Johns Hopkins, served as the Chief of Pediatric Anesthesia at Joe DiMaggio Children’s Hospital, and founded The Kaufmann Anti-Aging Institute, where she developed a comprehensive theory on aging science. She is an award-winning medical doctor. Struggling with sleep no matter what you try? In this deep-dive episode She; cell biologist, longevity expert, and author of The Kaufmann Protocol, explains the real reason millions of people can’t sleep: a failing circadian clock at the cellular level.Dr. Çavuşoğlu and Dr. Kaufmann break down:-How CLOCK, BMAL, cryptochrome, sirtuins, and NAD create your 24-hour rhythm-Why aging disrupts these proteins and shortens deep & REM sleep-Why melatonin only helps you fall asleep—not stay asleep-How esra improved her sleep without changing lifestyle-The supplement stack that restores circadian amplitude (selenium, spermidine, fucoidan, NAD, nobilitin)-Why glucose and especially fructose accelerate aging through AGEs-How to block sugar damage using carb blockers, SGLT2 inhibitors, aldose reductase inhibitors & lactoferrin-Dr. Kaufmann’s cell-based longevity medicine and future therapies #EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #SandraKaufmann Dr. Sandra Kaufmann, MD: Website: https://kaufmannprotocol.com/bio Instagram: https://www.instagram.com/kaufmannlongevity?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw== Special thanks to T.C. Istanbul Gedik Universityhttps://www.gedik.edu.tr/en/00:00-02:49 Introduction to the podcast and Dr. Sandra Kaufmann02:49-05:44 Why we can’t sleep?05:44-11:54 How the circadian clock actually works11:54-12:24 The facts about melatonin12:24-13:51 How sleep patterns change with age13:51-19:18 Supplement protocol that fixed Esra’s sleep19:18-20:33 How cells lose the ability to create high-quality proteins over time20:33-24:17 Circadian clock. How sleep rhythms affect DNA repair, telomere stability, and cancer risk. 24:17-28:43 Cell-based longevity medicine28:43-30:49 The truth about statins and cholesterol30:49-35:14 Supplements for sleep35:14-37:00 Glucose and fructose cause age you faster 37:00-45:18 Exosomes, plasmapheresis, and gene therapy45:18-50:39 “Cheating” the sugar damage50:39-52:12 Aldose reductase inhibitors52:12-53:21 How diabetes can be reversed with cellular repair53:21-54:14 AGE sponge: Lactoferrin54:14-54:58 Wrap up.*To subscribe to our channel* https://www.youtube.com/@ayikkafa *Dr. Esra Çavuşoğlu, PhD*Instagram: https://www.instagram.com/dresracavusogluhttps://www.instagram.com/longevilab Web: https://www.longevilab.com/hakkimizda#esra-cavusoglu *To Reach Us * [email protected]*About Ayık Kafa*Dr. Esra Çavuşoğlu, PhD, took her studies, starting from her personal treatment experiences and continuing with her clinical psychology education, to the next level by completing her PhD focused on Addiction. Dr. Esra in Ayık Kafa podcast discusses the world’s latest technologies, protocols, products and research in the fields of Biohacking and Longevity, while sharing first-hand information and experiences about the Disease of Addiction, as well as her latest academic studies.*About Dr. Esra Çavuşoğlu, PhD*Longevilab’s founder, Dr. Esra, is a United States and internationally trained clinical psychologist and a certified addiction therapist in New York. She served as International Development Advisor on the Yale University Faculty of Medicine Clinical Advisory Board. She is the founder and supervisor of Gaziantep Oya Bahadır Yüksel Rehabilitation Center, Dr. Esra is the designer and implementer of the Turkey Rehabilitation Model. Dr. Esra founded the Contemporary Addiction Studies Association (ÇABAÇAD) in order to combat Turkey’s growing addiction problem.